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Contraindicated (1)phenobarbital will lessen the level or impact of naloxegol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Utilization of naloxegol with robust CYP3A4 inducers is just not proposedMediates hepatobiliary excretion of diverse natural anions. May possibly function to be a mobile cisplatin transporter.Nuc